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In most of mammalian embryos, gonadal sex differentiation occurs inside the maternal uterus before birth. In several fetal ovarian grafting experiments using male host mice, an experimental switch from the maternal intrauterine to male-host environment gradually induces partial masculinization of the grafted ovaries even under the wild-type genotype. However, either host-derived factors causing or molecular basis underlying this masculinization of the fetal ovaries are not clear.

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Molecular mechanisms underlying sexual reversal in vertebrates, particularly sRNAs involved in this process, are largely unknown. By deep-sequencing of small RNA transcriptomes in combination with genomic analysis, we identified a large amount of piRNAs and miRNAs including over 1, novel miRNAs, which were differentially expressed during gonad reversal from ovary to testis via ovotesis. Biogenesis and expressions of miRNAs were dynamically changed during the reversal.

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Reproduction is the process by which organisms make more organisms like themselves. But even though the reproductive system is essential to keeping a species alive, unlike other body systems, it's not essential to keeping an individual alive. In the human reproductive process, two kinds of sex cells, or gametes GAH-meetzare involved.

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While sex may be filled with orgasms that make some women see rainbows, that isn't the case for everyone. Here's what might be going on if you're feeling more pain than pleasure. If you get a dull, deep aching sensation in your lower belly whenever your partner thrusts deep, they might be hitting your cervix.

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Jane Ussher receives funding from the Australian Research Council for research on sexuality. Republish our articles for free, online or in print, under Creative Commons licence. Is she a nymphomaniac?

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Ovarian Graafian follicles and corpus luteum steroid hormone synthesis. Description: Ovary and Follicle Development Learning Objectives Explain the regular progression of follicular development and atresia occurring in a cyclic fashion in the primary ovary Describe the role of FSH and LH in driving follicular development. Diagram how estrogen is produced by cells of the theca interna and zone granulosa.

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